Best against enemy fighters and melee assassins who rely on sustained physical damage. The stacking attack reduction makes long trades impossible for them. Prefer over Blade Armor when the enemy damage dealer is melee (Lesley melee combos still trigger it, but Blade Armor punishes ranged autos more).

Best on

Tanks, off-tanks — anyone expected to eat extended physical trades.

Consider instead

Blade Armor

Dominance Ice

Heroes that build Antique Cuirass